Can environmental impacts on genes explain why ALS affects people differently?

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Over the last decade, scientists have discovered many genes related to ALS, but there are still many questions about how mutations in those genes spark the development of the disease. The range of onset for ALS is wide: it can occur anytime in adulthood. The disease duration is usually two to five years after diagnosis but can range from six months to more than 20 years. Why does the disease manifest so differently among those who develop it — even among those who have the same ALS-related gene mutations?

Dr. Rogaeva and Dr. Zinman, two ONDRI investigators are dedicated to Neurodegenerative Diseases research, bringing light into genes and ALS.