An important new ONDRI publication, the result of many years of work by an eminent team of scientists, establishes the link between eye movement parameters, a set of cognitive measures, and associated differences in neurodegenerative diseases.
Good fats can go bad in diseased small blood vessels. An innovative ONDRI study uncovers a new blood marker and therapeutic target in small vessel disease.
Mobility aids can promote safe and effective walking, support independence and help reduce the risk of falls. But are they used as prescribed?
New exploratory research led by Dr. Bryan Wong, an optometrist and medical doctor currently completing a residency in ophthalmology at the University of Toronto, provides insights into this developing story and builds on inconsistent findings in past studies.
Brain imaging involves inherent distortions. This is a particular concern when conducting a multi-site study, where images generated in different environments need to be comparable. ONDRI researchers adapted and validated a purposely designed protocol to help promote standardized imaging results.
ONDRI’s clinical assessment platform is in the background of all ONDRI studies, providing clinical detail on study participants that can help illuminate new findings, or verify hypotheses.
Empathy is known to be associated with FTD. But is it associated with other neurodegenerative and cerebrovascular diseases and what biological factors may be contributing? A new ONDRI study set out to explore these issues.
Recent studies have suggested that magnetic resonance imaging–visible perivascular spaces (PVS) in the basal ganglia (BG-PVS) of patients with Parkinson’s disease (PD) may be markers of motor disability and cognitive decline. A new ONDRI study explores this issue further.
The neuroimaging platform has been a key part of ONDRI since the design and implementation of the Foundational Study. Read some key observations about the neuroimaging data, past and upcoming studies from two ONDRI researchers.
Studies of neurodegenerative diseases typically group people based on their clinical diagnosis. Yet there is so much genetic overlap between diseases, that this approach needs to be rethought.
Young or early-onset dementia refers to dementia symptoms diagnosed in a person who is under the age of 65. There are some differing considerations to be taken into account when diagnosing young onset dementia.
A new study published by Allison Dilliott PhD, et al show how a well known gene variant influences cognition no matter the neurodegenerative diagnosis, which may help pave the way.
We set goals for ourselves every day. We write them down them, we measure them, we tick them off. Setting measurable goals has been used for years in business settings, in cognitive behaviour therapy and many other contexts. Achieving our goals then contributes to...
Sleep is a crucial part of our health and wellbeing. Not only do we feel rested after a good night’s sleep, but behind the scenes, important functions are taking place which help keep us healthy. Our brain clears out the day’s metabolic waste while we sleep. Blockage in the perivascular spaces, through which the waste flows, may mean we sleep longer, to make up for it.
ONDRI researchers Miracle Ozzoude, Dr. Joel Ramirez and colleagues have devised methods that substantially improve accuracy of cortical thickness measures. This work also provides measures of cortical thinness in patients with focal stroke and extreme white matter disease, which could not have been done prior to their work.
ONDRI researchers Edward Ntiri, Dr. Maged Goubran et al set out to devise improved algorithms to accurately and efficiently measure whole brain volume and ventricular volume in people living with neurodegenerative diseases. Their methods have meant dramatic improvements in image processing, with exciting clinical implications.
It has long been believed that speaking more than one language on a regular basis may help boost brain function and possibly preserve the brain as it ages. An innovative ONDRI study explores this issue.