Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative

September 2019 
Journal: The Canadian Journal of Neurological Sciences
Lead Author: Allison A Dilliott

All Authors: Allison A. Dilliott, Emily C. Evans, Sali M.K. Farhan, Mahdi Ghani, Christine Sato, Ming Zhang, Adam D. McIntyre, Henian Cao, Lemuel Racacho, John F. Robinson, Michael J. Strong, Mario Masellis, Dennis E. Bulman, Ekaterina Rogaeva, Sandra E. Black, Elizabeth Finger, Andrew Frank, Morris Freedman, Ayman Hassan, Anthony Lang, Christen L. Shoesmith, Richard H. Swartz, David Tang-Wai, Maria Carmela Tartaglia, John Turnbull, Lorne Zinman, the ONDRI Investigators, Robert A. Hegele

There are changes that can occur within one’s DNA that are quite common in the general population, but which can lead to an increased risk of neurodegeneration. One example of this is the well-known genetic risk factor for late-onset Alzheimer’s disease (AD) found within the apolipoprotein E (APOE) gene. This study examined common APOE gene variants and microtubule-associated protein tau (MAPT) gene variants and their association with the five ONDRI neurodegenerative diseases.