MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease

May 2021
Journal: Sleep Medicine
Lead Author: Joel Ramirez

All Authors: Joel Ramirez, Melissa F. Holmes, Courtney Berezuk, Donna Kwan, Brian Tan, Derek Beaton, Christopher J.M. Scott, Miracle Ozzoude, Fuqiang Gao, Di Yu, Walter Swardfager, Jane Lawrence-Dewar, Dar Dowlatshahi, Gustavo Saposnik, Mark I. Boulos, Brian J. Murray, Sean Symons, Robert Bartha, Sandra E. Black, Richard H. Swartz, Andrew Lim and ONDRI Investigators

Cerebrospinal fluid (csf) flows through the brain, particularly during sleep, and serves a waste clearing function. The size or volume of the space around the brain’s blood vessels (perivascular space) is an indicator of the degree of csf flow – the higher the volume, the more likely the dysfunction in this clearing mechanism. This research, which uses ONDRI’s Foundational study data, tested whether larger than normal perivascular space volumes were associated with compensatory individual sleep behaviours.​