Foundational Study

The beginning of ONDRI’s research:
2013-2018

ONDRI’s Foundational Study recruited cohorts (or groups) of participants living with one of 5 diseases of interest

Diverse cohorts

A total of 520 participants with lived experience were recruited, along with their care partners. The cohorts spanned site labs across the province, making the study geographically diverse, with richer data. 

Foundational Study cohorts:

Alzheimer's/mild cognitive impairment participants

Frontotemporal lobar degeneration participants

Amyotrophic Lateral Sclerosis (ALS) participants

Parkinson's disease participants

Cerebrovascular disease participants

Video: Brief description of ONDRI foundational study by Doug Munoz PhD

5 Diseases – 8 assessments – 520 participants (plus care partners)

ONDRI research was designed to uncover cross-disease breakthroughs by having participants undergo the same 8 assessments (study protocols).

The resulting database holds promising data on disease progression and other health and lifestyle factors. This allows scientists to make exciting comparisons within diseases (e.g. across multiple assessments), and between diseases.

ONDRI participants showed incredible commitment

Being a Foundational Study participant required spending 3 days/year, over 3 years, attending assessment appointments. ONDRI researchers deeply appreciate this commitment.

ONDRI’s multi-dimensional data

ONDRI’s rich, deep trove of Foundational study data can understood using the 3 dimensions of the cube on the left:

  • Assessment platforms – 8 
  • Diseases – 5 
  • Timeframe – 3 years (minimum), including baseline

Related resources:

The Ontario Neurodegenerative Disease Research Initiative (ONDRI) – Foundational study description

Get notified of ‘big data’ release

OBI is set to release baseline data from the ONDRI Foundational study in the later months of 2021. Hundreds of researchers are already waiting. Sign up to be notified when it’s available, along with other ONDRI updates. 

This is why ONDRI created novel processes to standardize data

Each site lab produced data in technology-specific formats (to give an example, using different branded MRI machine formats). ONDRI researchers used special standardization tools and techniques to address this variation and enable effective cross-platform, cross-disease analysis of the data.