Retinal nerve fibre layer in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

October 2022
Journal: Frontiers in Neuroscience
Lead Author: Bryan M. Wong

All Authors: Bryan M. Wong, Christopher Hudson, Emily Snook, Faryan Tayyari, Hyejung Jung, Malcolm A. Binns, Saba Samet, Richard W. Cheng, Carmen Balian, Efrem D. Mandelcorn, Edward Margolin, Elizabeth Finger, Sandra E. Black, David F. Tang-Wai, Lorne Zinman, Brian Tan, Wendy Lou, Mario Masellis, Agessandro Abrahao, Andrew Frank, Derek Beaton, Kelly M. Sunderland, Stephen R. Arnott, ONDRI Investigators, Maria Carmela Tartaglia, and Wendy V. Hatch


This study examined if spectral-domain optical coherence tomography (SD-OCT) can differentiate, in living organisms, the difference in the thickness of both the peripapillary retinal nerve fibre layer (pRNFL) and the macula, between two distinct groups of participants in ONDRI’s Foundational Study: study participants with presumed tauopathy (progressive supranuclear palsy) and those with presumed TDP43 proteinopathy (amyotrophic lateral sclerosis and semantic variant primary progressive aphasia).