Small and Large Magnetic Resonance Imaging–Visible Perivascular Spaces in the Basal Ganglia of Parkinson’s Disease

April 2022 
Journal: Movement Disorders
Co-Lead Authors: Joel Ramirez, Stephanie A. Berberian

All Authors: Joel Ramirez, Stephanie A. Berberian, David P. Breen, Fuqiang Gao, Miracle Ozzoude, Sabrina Adamo, Christopher J.M. Scott, Courtney Berezuk, Vanessa Yhap, Tiago A. Mestre, Connie Marras, Maria C. Tartaglia, David Grimes, Mandar Jog, Donna Kwan, Brian Tan, Malcolm A. Binns, Stephen R. Arnott, Robert Bartha, Sean Symons, Mario Masellis, Sandra E. Black, Anthony E. Lang, ONDRI Investigators

Recent studies have suggested that magnetic resonance imaging–visible perivascular spaces (PVS) in the basal ganglia (BG-PVS) of patients with Parkinson’s disease (PD) may be markers of motor disability and cognitive decline. The aim of this study was to examine associations between quantitative measures of large and small BG-PVS, global cognition, and motor/nonmotor features in a multicenter cohort of patients with PD.