The utility of multivariate outlier detection techniques for data quality evaluation in large studies: an application within the ONDRI Project

May 2019 
Journal: BMC Medical Research Methodology
Lead Author: Kelly M Sunderland

All Authors: Kelly M. Sunderland, Derek Beaton, Julia Fraser , Donna Kwan, Paula M. McLaughlin, Manuel Montero-Odasso, Alicia J. Peltsch, Frederico Pieruccini-Faria, Demetrios J. Sahlas, Richard H. Swartz, ONDRI Investigators, Stephen C. Strother and Malcolm A. Binns

Large and complex studies are now routine; quality assurance (QA) and quality control (QC) procedures ensure reliable results and conclusions. This research determined that manual QC procedures are insufficient for large studies as many errors remain undetected.